James P Howard

Cardiology trainee in London

I'm a Wellcome Trust PhD Fellow and cardiology registrar at Imperial College London.

Some of my key publications are listed below; others are visible on my Google Scholar profile and CV.

Finally, I'm an amateur yet avid programmer and Pythonista. Some of my source code is available here on my GibHub.


Quantifying the 3 Biases

Circulation: Cardiovascular Quality and Outcomes

This meta-analysis demonstrates how adding a randomized control group to hypertension trials, without blinding, is almost useless. Bias in early denervation trials came from patients changing their medication adherence, or doctors making measurements in a biased way. In randomized but unblinded trials, this carried on happening.



This ambitious meta-analysis into cardiac stem cell therapy has been widely covered in the media, including in a Nature editorial. Other articles covering our meta-analysis include Forbes' article, "Stem Cell Therapy To Fix The Heart: A House Of Cards About To Fall?"



Early renal denervation trials showed office blood pressure reductions of ~30 mmHg, yet reductions in ambulatory blood pressures appear to be several-fold smaller. This paper correctly predicted, through meta-analysis of drug trials, the startlingly lower results seen in the landmark SYMPLICITY-HTN 3 trial. Our work has been covered by Forbes, Medscape and the Motley Fool

Big day bias

International Journal of Cardiology

After CONVERGE and Symplicity-HTN 3 demonstrated a huge disparity between results from unblinded/uncontrolled trials and the gold-standed double-blinded RCT trials, we wrote this paper to explain why and how researchers should minimise the effects of bias when designing hypertension trials.

Removing the hype from hypertension


An editorial published in the BMJ following the findings from the Symplicity-HTN 3 trial, re-iterating the importance of good trial design in hypertension.

Early STEMI discharge


We investigated the safety and feasibility of very early discharge 2 days following PPCI in selected low risk STEMI patients. Our data suggest that discharge of such patients two days after successful PPCI is feasible and safe. Over 40% of all patients with STEMI may be suitable for early discharge with important implications for healthcare costs.

Recent advances in antithrombotic treatment for acute coronary syndromes

Expert Review of Clinical Pharmacology

This review covers the evidence for anti-platelets and anti-coagulants in ACS

Ascites in constrictive pericarditis

Frontline Gastroenterology

An educational review and case series of constrictive pericarditis patients, emphasising how this disease may manifest in a variety of ways, leading to misdiagnosis. We covered two patients who were initially wrongly diagnosed as having hepatic or respiratory diseases.


Google Scholar metrics

Total publications: 61

Total citations: 817

H-index: 11


A bit more about my education, training and research interests to date.


My website covering the most important trials in cardiovascular medicine. Currently, with over 90 trials, it receives around 2000 visitors per month.

A quick guide to R

A quick cheat-sheet for performing basic statistical tests in the R programming language. Designed to accompany Stanford's free Medstats course.

NETFS Swap shop

In 2011 the North East Thames Foundation school allowed foundation doctors to swap their F2 jobs in a 'swap shop' for the first time. Unfortunately 'round robin' emails about swaps from 100+ candidates made the system unusable. I realised the need for a more efficient system and created a simple PHP-powered database. Doctors were able to find their name in the database on the website, sign-in, and tick which jobs they were interested in swapping to. The system then highlighted to each doctor who was interested in swapping with them.


Initially there were no good medical calculators for Windows Phone 7. I therefore worked to create a free alternative, FMCalc. The application is now on the official Windows Phone 7 marketplace and has been downloaded by over four thousand unique users in fifteen different countries.

About this site

How this site works; an explanation of how python can be used to 'program' websites dynamically and easily.